Structural analysis of DNA molecule in a confined shell

Recent advances in operating and manipulating DNA have provided unique experimental possibilities many fields of research, especially gene therapy. Researchers deployed techniques, theoretical, to study the structure changes due external perturbation. It is crucial understand structural dynamical molecules a confined state control self-assembly chamber or nano-channel for various applications. In current manuscript, we extend work effect confinement on thermal stability properties duplex DNA. The present an extension our previous research works (Maity et al., 2019; 2020). For considered 1 BNA chain that cylindrical geometry. How geometry affects opening other parameters molecule objective this manuscript. We used statistical model(PBD model) Molecular dynamics simulations purpose.